Study the Effect of Fenugreek Seeds on Gastric Ulcer in Experimental Rats

The aim of this study was to investigate the effect of fenugreek seeds on aspegic induced gastric mucosal ulcer in rats. Forty-eight male albino rats of Sprague Dawley strain were classified into normal control group and five aspirin induced gastric ulcer groups which divided into non treated control (+ve) and treated groups that were drug, fenugreek seeds extract, fenugreek oil and fenugreek powder groups. The results revealed that, final weight, weight gain and food efficiency ratio, gastric glutathione, catalase and superoxide dismutase and blood hemoglobin, packed cell volume, glutathione peroxidase, superoxide dismutase and malondialdehyde were significantly decreased in control (+ ve) group compared with normal control group. The volume of gastric juice, total acidity of gastric juice, nitric oxide and malondialdehyde were significantly increased in control (+ ve) group compared with normal control group. On the other side ,the drug, fenugreek extract, fenugreek oil and fenugreek powder rat groups showed a significant increase in final weight, weight gain and food efficiency ratio; gastric glutathione, catalase and superoxide dismutase and blood hemoglobin, packed cell volume, glutathione peroxidase and superoxide dismutase but showed a significant decrease in the values of gastric ulcer index, volume of gastric juice and total acidity, gastric nitric oxide and malondialdehyde and blood malondialdehyde compared with control (+ve) group. Fenugreek extract, fenugreek oil and fenugreek powder rat groups showed a significant decrease in curative ratio percentage and the decrease in total acidity percentage compared with drug group. These observations showed that fenugreek seeds possess antiulcer potential.